Motor Fluctuations

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safety

Integrated safety of levodopa-carbidopa intestinal gel from prospective clinical trials

By Anthony E. Lang MD, FRCPC,*, Ramon L. Rodriguez MD, James T. Boyd MD, Sylvain Chouinard MD, FRCPC, Cindy Zadikoff MD, Alberto J. Espay MD, John T. Slevin MD, MBA, Hubert H. Fernandez MD, Mark F. Lew MD, David A. Stein MD, Per Odin MD, PhD, Victor S.C. Fung MBBS, PhD, FRACP, Fabian Klostermann MD, PhD, Alfonso Fasano MD, PhD, Peter V. Draganov MD, Nathan Schmulewitz MD, Weining Z. Robieson PhD, Susan Eaton PharmD, Krai Chatamra PhD, Janet A. Benesh BSMT and Jordan Dubow MD

Continuous administration of levodopa-carbidopa intestinal gel (carbidopa-levodopa enteral suspension) through a percutaneous endoscopic gastrojejunostomy is a treatment option for advanced Parkinson disease (PD) patients with motor fluctuations resistant to standard oral medications. Safety data from 4 prospective studies were integrated to assess the safety of this therapy.

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