Motor Fluctuations

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  • Movement Disorders Clinical Practice
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l-dopa

Apomorphine Subcutaneous Injection for the Management of Morning Akinesia in Parkinson’s Disease

By Stuart Isaacson MD,*, Mark Lew MD, William Ondo MD, Jean Hubble MD, Thomas Clinch BS and Fernando Pagan MD

ABSTRACT Background In patients with motor fluctuations complicating Parkinson’s disease (PD), delays in time-to-ON with levodopa are common. This open-label study aimed to assess the effect of apomorphine on time-to-ON in PD patients with morning akinesia. Methods The safety population included 127 enrolled patients, and the full analysis set (FAS) included 88 patients. Patients completed…

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