Motor Fluctuations

Articles Collection

  • Movement Disorders
  • Movement Disorders Clinical Practice
MENU 
  • This article collection was made possible by Cynapsus.
  • Cynapsus

apomorphine

Apomorphine Subcutaneous Injection for the Management of Morning Akinesia in Parkinson’s Disease

By Stuart Isaacson MD,*, Mark Lew MD, William Ondo MD, Jean Hubble MD, Thomas Clinch BS and Fernando Pagan MD

ABSTRACT Background In patients with motor fluctuations complicating Parkinson’s disease (PD), delays in time-to-ON with levodopa are common. This open-label study aimed to assess the effect of apomorphine on time-to-ON in PD patients with morning akinesia. Methods The safety population included 127 enrolled patients, and the full analysis set (FAS) included 88 patients. Patients completed…

Read More

Apomorphine: A Potential Modifier of Amyloid Depositionin Parkinson’s Disease?

By Alison J. Yarnall MRCP, PhD, Tammaryn Lashley BSc, PhD, Helen Ling MRCP, PhD, Andrew J. Lees MD, FRCP, FMedSci, Shirley Y. Coleman MSc, PhD, Sean S. O'Sullivan MRCP, PhD, Yaroslau Compta MD, PhD, Tamas Revesz MD, FRCPath and David J. Burn MA, MD, FRCP*

Evidence from clinical and pathological studies suggests a role for both alpha-synuclein and amyloid-beta in the pathophysiology of dementia associated with PD. Recent work demonstrated improvement in memory and reduced amyloid-beta burden in transgenic murine Alzheimer’s models given subcutaneous apomorphine. The aim of this work was to determine whether antemortem exposure to apomorphine was associated with lower levels of amyloid-beta in brain tissue in a clinicopathological study of PD.

Read More

Apomorphine Therapy: The Hazard of Left Over Needles

By Bertrand Degos MD, PhD*, Sophie Aix CRNP, Emmanuel Roze MD, PhD and Marie Vidailhet MD

A 55-year-old patient with Parkinson’s disease (PD) was seen for a shoulder abscess. This abscess was related to the presence of a subcutaneous needle that was disconnected from the tubing used for continuous apomorphine therapy…

Read More