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amyloid

Apomorphine: A Potential Modifier of Amyloid Depositionin Parkinson’s Disease?

By Alison J. Yarnall MRCP, PhD, Tammaryn Lashley BSc, PhD, Helen Ling MRCP, PhD, Andrew J. Lees MD, FRCP, FMedSci, Shirley Y. Coleman MSc, PhD, Sean S. O'Sullivan MRCP, PhD, Yaroslau Compta MD, PhD, Tamas Revesz MD, FRCPath and David J. Burn MA, MD, FRCP*

Evidence from clinical and pathological studies suggests a role for both alpha-synuclein and amyloid-beta in the pathophysiology of dementia associated with PD. Recent work demonstrated improvement in memory and reduced amyloid-beta burden in transgenic murine Alzheimer’s models given subcutaneous apomorphine. The aim of this work was to determine whether antemortem exposure to apomorphine was associated with lower levels of amyloid-beta in brain tissue in a clinicopathological study of PD.

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