Motor Fluctuations

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  • Movement Disorders Clinical Practice
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add-on

Two-year, randomized, controlled study of safinamide as add-on to levodopa in mid to late Parkinson’s disease

By Rupam Borgohain DM*, Jozsef Szasz MD, Paolo Stanzione MD, Chandrashekhar Meshram DM, Mohit H. Bhatt DM, Dana Chirilineau MD, Fabrizio Stocchi MD, Valentina Lucini MD, Rodolfo Giuliani MD, Emma Forrest PhD, Patricia Rice PhD, Ravi Anand MD and the Study 018 Investigators

In a 6-month double-blind, placebo-controlled study of Parkinson’s disease patients with motor fluctuations, safinamide 50 and 100 mg/d significantly increased ON-time without increasing dyskinesia. Further long-term safinamide use in these patients was evaluated over an additional 18 months. Patients continued on their randomized placebo, 50, or 100 mg/d safinamide. The primary endpoint was change in Dyskinesia Rating Scale total score during ON-time over 24 months…

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