Motor Fluctuations

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Research Article

Randomized Trial of Safinamide Add-On to Levo dopa in Parkinson’s Disease With Motor Fluctuations

By Rupam Borgohain DM*, J. Szasz MD, P. Stanzione MD, C. Meshram DM, M. Bhatt DM, D. Chirilineau MD, F. Stocchi MD, V. Lucini MD, R. Giuliani MD, E. Forrest, P. Rice, R. Anand MD† and for the Study 016 Investigators

Levodopa is effective for the motor symptoms of Parkinson’s disease (PD), but is associated with motor fluctuations and dyskinesia. Many patients require add-on therapy to improve motor fluctuations without exacerbating dyskinesia. The objective of this Phase III, multicenter, double-blind, placebo-controlled, parallel-group study was to evaluate the efficacy and safety of safinamide…

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