Motor Fluctuations

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Editorial

Pharmacological insights into L-DOPA-induced motor fluctuations of patients with Parkinson disease

By Olivier Rascol

Clinical Investigation Center INSERM 1436, Department of Clinical Pharmacology and Neurosciences, University Hospital of Toulouse and University of Toulouse III, UMR Tonic 1214, NS-Park/FCRIN Network and NeuroToul COEN Center of Excellence in Neurodegeneration, Toulouse, France

The discovery 50 years ago of the spectacular efficacy of L-DOPA has revolutionized the treatment of Parkinson disease (PD), and indeed all modern Clinical Pharmacology.  However, within a few years, PD patients on chronic L-DOPA therapy almost inevitably face disabling periods of reduced benefit, known as motor and non-motor “fluctuations” 1. In 2016, adequate management…

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